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KMID : 0043320150380071304
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Archives of Pharmacal Research
2015 Volume.38 No. 7 p.1304 ~ p.1311
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Flavonoids from the aerial parts of Houttuynia cordata attenuate lung inflammation in mice
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Lee Ju-Hee
Ahn Jong-Min
Kim Jin-Woong
Lee Sang-Gook
Kim Hyun-Pyo
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Abstract
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The aerial parts of Houttuynia cordata used for treating inflammation-related disorders contain flavonoids as major constituents. Since certain flavonoids possess anti-inflammatory activity, especially in the lung, the pharmacological activities of H. cordata and the flavonoid constituents were evaluated using in vitro and in vivo models of lung inflammation. The 70 % ethanol extract of the aerial parts of H. cordata inhibited the production of inflammatory biomarkers IL-6 and NO in lung epithelial cells (A549) and alveolar macrophages (MH-S), respectively. And the same plant material, administered orally (100 and 400 mg/kg), significantly inhibited lung inflammatory response in a mouse model of lipopolysaccharide (LPS)-induced acute lung injury. From the extract, major flavonoids including afzelin, hyperoside and quercitrin were successfully isolated and they also attenuated LPS-induced lung inflammation in mice by oral administration. In particular, quercitrin showed most potent activity at 100 mg/kg. These results demonstrate for the first time that H. cordata and three flavonoid constituents have a therapeutic potential for treating lung inflammatory disorders.
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KEYWORD
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Houttuynia cordata, Flavonoid, Quercitrin, Lung inflammation, Cytokine
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